The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis
نویسندگان
چکیده
منابع مشابه
The potential role for use of mitochondrial DNA copy number as predictive biomarker in presbycusis
OBJECTIVES Age-related hearing impairment, or presbycusis, is the most common communication disorder and neurodegenerative disease in the elderly. Its prevalence is expected to increase, due to the trend of growth of the elderly population. The current diagnostic test for detection of presbycusis is implemented after there has been a change in hearing sensitivity. Identification of a pre-diagno...
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Mammalian mitochondrial DNA (mtDNA) is a small, maternally inherited genome that codes for 13 essential proteins in the respiratory chain. Mature oocytes contain more than 150 000 copies of mtDNA, at least an order of magnitude greater than the number in most somatic cells, but sperm contain only approximately 100 copies. Mitochondrial oxidative phosphorylation has been suggested to be an impor...
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ژورنال
عنوان ژورنال: Therapeutics and Clinical Risk Management
سال: 2016
ISSN: 1178-203X
DOI: 10.2147/tcrm.s117491